TRIVIA : Tetralogy of Fallot Research for Improvement of Valve replacement Intervention : A bridge across the knowledge gap

Tetralogy of Fallot (ToF) is the most prevalent cyanotic congenital heart defect. The surgical repair is usually done before one year of age and the short-term results are usually very good. However, the surgical repair cannot always correct the defect completely. Some patients may develop complications, often several years after the repair.  Many patients will also need one or more cardiac interventions during their lifetime. To this day, many questions remain regarding the long-term management of ToF.

The TRIVIA study aims to shed light on the long-term outcomes of patients with ToF. We want to evaluate and compare the impact of different treatments on patients with ToF. Specifically, the study aims to:

  • describe the long-term clinical outcomes of ToF based on cardiac anatomy factors at birth, and on the presence of genetic conditions;
  • evaluate the long-term clinical outcomes of different surgical strategies used to repair ToF;
  • evaluate the long-term impact of pediatric pulmonary valve replacement on long-term clinical outcomes.

TRIVIA is a retrospective population-based cohort. It includes all patients born in Quebec with a ToF between 1980 and 2017. The database pools administrative data from the health system and clinical data from the four pediatric cardiology centers in Québec. The TRIVIA study will help understand the effect of risk factors and reinterventions on the incidence of adverse cardiovascular events.


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